I’ve been very happy with the Yakima On Ramp for just this reason. After hurting my back once when I was younger, I never take chances anymore.
With the On Ramp, you can simply walk your bike up and fasten it tight.
Nice features include a 132 lb weight capacity (up to two 66 lb bikes).
Each bike is secured at 3 points…..a strap on the frame, and one strap for the bottom of each wheel. The latter is a great option for bikes with fenders.
The wheel trays are highly adjustable, as are the frame clamps, making the rack customizable for almost any bike.
Super fat wheels might be an issue, but I think you can get an adapter for those. My Aventon Pace 500 wheels fit perfectly.
The rack folds up nicely when not in use. I needed a hitch extender, though, to clear the spare tire on my Jeep.
The nicest feature, IMO, is the loading ramp, which is particularly useful with heavy ebikes. The ramp screws into the rack itself, and is easily released and secured with a hand knob (no tools) and does not require storage in your vehicle.